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Christopher L Carroll Selected Research

compound 30

10/2021Discovery of 6-[(3S,4S)-4-Amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-2-methyl-3,4-dihydropyrimidin-4-one (IACS-15414), a Potent and Orally Bioavailable SHP2 Inhibitor.

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Christopher L Carroll Research Topics

Disease

16Asthma (Bronchial Asthma)
02/2016 - 03/2005
8Status Asthmaticus
05/2013 - 03/2006
6COVID-19
05/2022 - 01/2020
5Critical Illness (Critically Ill)
05/2022 - 06/2013
5Craniocerebral Trauma (Head Injury)
01/2022 - 12/2014
4Neoplasms (Cancer)
10/2021 - 07/2010
4Infections
01/2020 - 01/2017
4Bronchiolitis
08/2019 - 09/2012
3Brain Injuries (Brain Injury)
01/2021 - 12/2014
3Sepsis (Septicemia)
11/2020 - 01/2020
3Respiratory Insufficiency (Respiratory Failure)
08/2012 - 03/2006
2COVID-19 related pediatric multisystem inflammatory disease
01/2021 - 01/2021
2Fever (Fevers)
01/2021 - 01/2020
2Septic Shock (Toxic Shock Syndrome)
01/2020 - 01/2020
2Inflammation (Inflammations)
01/2020 - 12/2006
2Bronchial Spasm
11/2014 - 10/2004
2Obesity
06/2009 - 11/2006
2Pulmonary Hypertension
09/2005 - 12/2002
1Disease Progression
05/2022
1Sarcoma (Soft Tissue Sarcoma)
10/2021
1Carcinosarcoma
10/2021
1Shock
01/2021
1Left Ventricular Dysfunction
01/2021
1Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
11/2020
1Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome)
01/2020
1Vascular Diseases (Vascular Disease)
01/2019
1Cardiotoxicity
11/2014
1Heart Arrest (Cardiac Arrest)
01/2013
1Hypersensitivity (Allergy)
08/2011
1Acute Lung Injury
11/2010
1Hemorrhage
07/2010
1Chronic Disease (Chronic Diseases)
05/2010
1Barotrauma
06/2008
1Pediatric Obesity
11/2006
1Congenital Heart Defects (Congenital Heart Defect)
09/2005
1Hypoxia (Hypoxemia)
12/2002

Drug/Important Bio-Agent (IBA)

6Albuterol (Salbutamol)FDA LinkGeneric
01/2017 - 10/2004
3Adrenal Cortex Hormones (Corticosteroids)IBA
06/2013 - 12/2006
3Terbutaline (Brethaire)FDA LinkGeneric
07/2008 - 04/2006
2Retinaldehyde (Retinal)IBA
01/2021 - 01/2019
2RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA
01/2021 - 01/2020
2Biomarkers (Surrogate Marker)IBA
01/2020 - 01/2020
2Amino AcidsFDA Link
03/2012 - 05/2009
2Epoprostenol (Prostacyclin)FDA LinkGeneric
09/2005 - 12/2002
1compound 30IBA
10/2021
1Phosphoric Monoester Hydrolases (Phosphatases)IBA
10/2021
1Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA
10/2021
1Mitogen-Activated Protein KinasesIBA
10/2021
1Histones (Histone)IBA
10/2021
1Proteins (Proteins, Gene)FDA Link
10/2021
1AT 61IBA
01/2021
1GlucocorticoidsIBA
01/2021
1Intravenous Immunoglobulins (IVIG)FDA Link
01/2021
1Biological ProductsIBA
01/2021
1Tyrosine Kinase InhibitorsIBA
11/2020
1Pharmaceutical PreparationsIBA
11/2020
1osimertinibIBA
11/2020
1GoldIBA
01/2020
1Oxygen (Dioxygen)IBA
01/2019
1MagnesiumIBA
02/2016
1MethylprednisoloneFDA LinkGeneric
06/2013
1Anesthetics (Anesthetic Agents)IBA
05/2013
1beta Adrenergic ReceptorsIBA
03/2012
1Irritants (Vesicants)IBA
08/2011
1AllergensIBA
08/2011
1Hemostatics (Antihemorrhagics)IBA
07/2010
1helioxIBA
05/2010
1Bronchodilator Agents (Bronchodilators)IBA
06/2009
1arginylarginine (Arg-Arg)IBA
05/2009
1Indicators and Reagents (Reagents)IBA
03/2005
1Nitric Oxide (Nitrogen Monoxide)FDA Link
12/2002

Therapy/Procedure

22Therapeutics
05/2022 - 09/2005
9Critical Care (Surgical Intensive Care)
01/2022 - 01/2019
7Length of Stay
12/2016 - 04/2006
4Resuscitation
01/2020 - 07/2010
4Positive-Pressure Respiration (Positive End-Expiratory Pressure)
07/2014 - 03/2006
4Artificial Respiration (Mechanical Ventilation)
08/2012 - 06/2008
2Cardiopulmonary Resuscitation (CPR)
12/2015 - 12/2014
1Cannula
08/2019
1Noninvasive Ventilation
08/2019
1Enteral Nutrition (Feeding, Tube)
10/2015
1MT protocol
07/2010
1Hepatectomy
07/2010
1Metered Dose Inhalers (Metered Dose Inhaler)
06/2009
1Nebulizers and Vaporizers (Inhaler)
06/2009
1Duration of Therapy
11/2006